{"id":11787,"date":"2023-07-07T17:15:21","date_gmt":"2023-07-07T17:15:21","guid":{"rendered":"https:\/\/maxani.nl\/?page_id=11787"},"modified":"2025-05-19T16:00:41","modified_gmt":"2025-05-19T16:00:41","slug":"masivet-informatie-voor-dierenartsen","status":"publish","type":"page","link":"https:\/\/maxani.nl\/en\/masivet-informatie-voor-dierenartsen\/","title":{"rendered":"Masivet information for veterinarians"},"content":{"rendered":"<section class=\"section\" id=\"section_575081796\">\n\t\t<div class=\"section-bg fill\" >\n\t\t\t\t\t\t\t\t\t\n\t\t\t\n\t<div class=\"is-border\"\n\t\tstyle=\"border-color:rgb(235, 235, 235);border-width:1px 0px 0px 0px;\">\n\t<\/div>\n\n\t\t<\/div>\n\n\t\t\n\n\t\t<div class=\"section-content relative\">\n\t\t\t\n\n<div class=\"row\"  id=\"row-312370532\">\n\n\n\t<div id=\"col-1157463691\" class=\"col medium-8 small-12 large-8\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n<div class=\"pp-heading  pp-center\">\u00a0<\/div>\n<div class=\"pp-sub-heading\">\n<h1><span style=\"font-size: 25.92px; color: #333333;\">Masivet\u00ae information for veterinarians<\/span><\/h1>\n<div class=\"pp-sub-heading\">\n<p>Masivet\u00ae is intended for the treatment of inoperable mast cell tumors in dogs (grade 2 or 3) or as post-treatment after (partial) removal of the tumor. The drug is a tyrosine kinase inhibitor and similar to Palladia\u00ae. Masivet\u00ae acts on the KIT receptor. This tyrosine kinase receptor regulates the growth or cell division of certain cells. In 15-40% of mast cell tumors, the cancer arises because there is damage to the KIT receptor. The receptor is on \"on\" all the time, and therefore the cells keep growing and dividing. Masivet\u00ae turns the KIT receptor \"off\" again. Administration is via 50 mg or 150 mg tablets. The tablets should not be broken.<\/p>\n<p>Take\u00a0<a href=\"https:\/\/maxani.nl\/en\/contact\/\">telephone contact<\/a>\u00a0contact Maxani if you are a veterinarian wishing to order Masivet\u00ae for the first time or would like more information about Masivet\u00ae. If you would like to place a repeat order, please log into the\u00a0<a href=\"https:\/\/maxani.nl\/en\/webshop\/\">webshop<\/a>. For pet owners, this product is only available through your veterinarian. More information about Masivet\u00ae can be found below.<\/p>\n<p>Masivet\u00ae is shipped and billed from AB Science in France. Delivery time is therefore 4 to 5 working days. One jar of Masivet\u00ae contains 30 tablets.<\/p>\n<ul>\n<li>50 mg Masivet\u00ae, registration number: 100191<\/li>\n<li>150 mg Masivet\u00ae, registration number: 100198<\/li>\n<\/ul>\n<h4>\u00a0<\/h4>\n<h4>How does Masivet\u00ae work?<\/h4>\n<p>Masivet\u00ae contains the active ingredient masitinib. Masitinib is a Protein Tyrosine Kinase (PTK) inhibitor to treat mast cell tumors that acts on c-KIT. C-KIT is a receptor for mast cell growth factor and is found in the cell wall. C-KIT is found in all humans and animals and plays an important role in the normal physiology of the cell. C-KIT plays a role in communication, development, division and growth of cells through phosphorylation of proteins. It functions as a kind of on\/off switch for these cell functions. Mutations in the c-KIT gene are found in 20% of mast cell tumors in dogs. C-KIT is a proto\/oncogene, which when mutated can cause increased proliferation. Another cause of mast cell tumors is that the c-KIT is continuously \"on\" without signaling by binding mast cell growth factor. This c-KIT seems 'addicted to ATP' and thus continues to phosphorylate proteins and transmit signals to growth and division in the cell. Thus, in most cases, a c-KIT test does not reveal whether or not treatment with Masivet\u00ae is successful, as it looks for a gene mutation that is the cause in only 20% of mast cell tumors.<\/p>\n<\/div>\n<\/div>\n\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n\t<div id=\"col-384212875\" class=\"col medium-4 small-12 large-4\"  >\n\t\t\t\t<div class=\"col-inner\"  >\n\t\t\t\n\t\t\t\n\n\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\n\n<\/div>\n\n\t\t<\/div>\n\n\t\t\n<style>\n#section_575081796 {\n  padding-top: 60px;\n  padding-bottom: 60px;\n  min-height: 300px;\n}\n<\/style>\n\t<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-blank.php","meta":{"footnotes":""},"class_list":["post-11787","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Masivet informatie voor dierenartsen - Maxani Animal Healthcare BV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/maxani.nl\/en\/masivet-informatie-voor-dierenartsen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Masivet informatie voor dierenartsen - Maxani Animal Healthcare BV\" \/>\n<meta property=\"og:url\" content=\"https:\/\/maxani.nl\/en\/masivet-informatie-voor-dierenartsen\/\" \/>\n<meta property=\"og:site_name\" content=\"Maxani Animal Healthcare BV\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-19T16:00:41+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/maxani.nl\/masivet-informatie-voor-dierenartsen\/\",\"url\":\"https:\/\/maxani.nl\/masivet-informatie-voor-dierenartsen\/\",\"name\":\"Masivet informatie voor dierenartsen - 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